The peer-reviewed research behind every ingredient in Daily Beets. Published studies, dosage comparisons, and mechanisms of action — compiled because we believe you deserve to see exactly what we put in and why.
A note on transparency: Daily Beets has not been independently clinically trialled as a finished product. The evidence presented here relates to individual ingredients and their studied roles in cardiovascular support. We believe you deserve access to the same research that informed our formulation decisions.
Daily Beets contains 11 ingredients, but the formula is built around four primary actives at dosages supported by published clinical research. The remaining seven ingredients are included as a supporting antioxidant and anti-inflammatory blend at lower doses. We want to be clear about this distinction.
Every primary active in Daily Beets is dosed based on levels used in published clinical trials. The bars show our dose relative to the researched range.
Beetroot is one of the richest dietary sources of inorganic nitrate, which the body converts to nitric oxide (NO) through the nitrate-nitrite-NO pathway. This pathway is independent of the endothelial NOS pathway that declines with age, making it a key supplementation target.
Dietary nitrate from beetroot is reduced to nitrite by oral bacteria, then further converted to nitric oxide in the stomach and circulation. NO relaxes vascular smooth muscle, promoting vasodilation and reducing peripheral resistance. A secondary, nitrate-independent pathway also contributes via beetroot's polyphenol content.
Moderate evidence quality. Consistent SBP reduction in hypertensive patients.
Higher doses associated with greater systolic reduction. Authors recommended longer-term trials in higher-risk populations.
Notably, nitrate-depleted beetroot juice still reduced BP (smaller effect), indicating additional bioactive compounds contribute beyond nitrate conversion alone.
Supports the case for consistent daily supplementation rather than intermittent use. Effect was not sustained after stopping.
| Source | Dosage | Form |
|---|---|---|
| Meta-analysis range (Bahadoran 2017) | 70–500 mL juice/day | Juice |
| Typical concentrated shot | 70 mL (≈ 6.5 mmol nitrate) | Juice concentrate |
| Standard supplement dose | 500–1,000 mg extract | Capsule |
| Daily Beets | 200mg 50:1 extract (equiv. 10,000mg raw) | Capsule |
Hibiscus sabdariffa (roselle) has been used traditionally for blood pressure management across multiple cultures. Modern research has identified anthocyanins and polyphenolic compounds as the primary bioactive agents, with mechanisms including ACE inhibition and antioxidant activity.
Hibiscus anthocyanins inhibit angiotensin-converting enzyme (ACE), reducing the production of angiotensin II — a potent vasoconstrictor. Additional polyphenolic compounds provide antioxidant protection to vascular endothelium and may support nitric oxide bioavailability.
Diastolic reductions were comparable to some antihypertensive medications. Greater effects in participants with elevated baseline BP.
No significant difference found between hibiscus and active antihypertensive drugs. However, less effective in patients with metabolic syndrome.
Double-blind, placebo-controlled. Dosage: 3 x 240 mL brewed hibiscus tea daily (approx. 3g dried hibiscus per serving).
| Source | Dosage | Form |
|---|---|---|
| McKay et al. (2010) | ~9g dried hibiscus/day | Brewed tea (720 mL) |
| Jalalyazdi et al. (2019) | 2.5g dried hibiscus/day | Brewed tea (480 mL) |
| Typical extract supplement | 250–500mg 10:1 extract | Capsule |
| Daily Beets | 500mg 10:1 extract (equiv. 5,000mg raw) | Capsule |
Grape seed extract is rich in oligomeric proanthocyanidins (OPCs), which have demonstrated antioxidant, anti-inflammatory, and vasorelaxant properties. Research suggests effects on both blood pressure and heart rate.
OPCs in grape seed extract enhance endothelial nitric oxide synthase (eNOS) activity, promoting NO production. They also reduce oxidative stress on vascular endothelium and may inhibit ACE activity, contributing to vasodilation and reduced peripheral resistance.
Greater effects observed in younger subjects (<50 years), obese individuals, and those with metabolic syndrome.
Dose-response analysis. May be beneficial for CVD prevention via hypotensive and heart rate-lowering properties.
Double-blind, placebo-controlled. Effect reversed after 4-week discontinuation — supporting daily consistent use.
| Source | Dosage |
|---|---|
| Park et al. (2016) RCT | 300mg/day |
| Typical supplement range | 100–300mg/day |
| Daily Beets | 200mg/day |
CoQ10 is a naturally occurring antioxidant involved in mitochondrial energy production. Endogenous levels decline with age, and statin medications further deplete CoQ10. Research shows consistent systolic blood pressure benefits, particularly at the 100-200mg dosage range.
CoQ10 improves endothelial function by reducing oxidative stress and enhancing nitric oxide bioavailability. It supports mitochondrial ATP production in cardiac muscle cells and has been shown to reduce peripheral vascular resistance through improved endothelial-dependent vasodilation.
U-shaped dose-response: lower doses (100-200mg) showed greater efficacy than higher doses. Effective as adjunctive therapy for systolic hypertension.
May help lower systolic pressure specifically in metabolic disease patients. Consistent with the larger 2025 meta-analysis findings.
Earlier, smaller analysis showing larger effect sizes. No significant adverse effects reported. Larger 2025 meta-analysis shows more conservative but consistent results.
| Source | Dosage |
|---|---|
| Karimi et al. (2025) — optimal range | 100–200mg/day |
| British Heart Foundation recommendation | 100–300mg/day |
| Daily Beets | 100mg/day |
The following seven ingredients are included at doses below the levels typically studied in clinical trials. Their role is to provide a broad spectrum of complementary antioxidant and anti-inflammatory compounds within the overall formula. We are transparent that these are supporting ingredients, not primary actives, and we do not make individual efficacy claims for them at these dosages.
Our position on these ingredients: Each of the compounds listed above has published research supporting a role in cardiovascular health at higher doses. At the doses included in Daily Beets, their individual clinical impact is uncertain. We include them for their combined antioxidant and anti-inflammatory contribution to the formula, not as standalone therapeutic agents. We believe this transparency strengthens rather than weakens the case for our formulation — the evidence-based heavy lifting is done by beetroot, hibiscus, grape seed extract, and CoQ10.
Studied at 140mg+ CGA/day. Daily Beets dose (15mg extract) is substantially below this range.
Studied at 208–1,344mg/day. Daily Beets dose (10mg) is well below this range.
Comprehensive review of curcumin's anti-inflammatory and NO-enhancing mechanisms. Clinical trials typically used 500mg+ enhanced bioavailable formulations. Daily Beets dose (6mg standard) is modest and serves a supporting role.
No significant BP effect. Reduced CRP and TNF-α at studied doses (480mL juice/day). Daily Beets dose (equiv. 50mg powder) is substantially below studied amounts. Included for its anti-inflammatory profile.
Relevant to the target age group (65-80) but at substantially higher doses (480mL/day) than included in Daily Beets.
Included for its anthocyanin content, which supports endothelial function. At 5mg, this is a trace amount included as part of the broader antioxidant profile rather than a clinically dosed active ingredient. No individual efficacy claim is made at this dosage.
Provides vitamin K, folate, and flavonoids as part of the supporting antioxidant blend. At 5mg (equiv. 25mg powder), this is a trace amount contributing to the overall micronutrient profile. No individual efficacy claim is made at this dosage.
Contains sulforaphane, a compound known to activate the Nrf2 antioxidant pathway. At 4mg (equiv. 20mg powder), this is a trace amount included for its complementary antioxidant contribution. No individual efficacy claim is made at this dosage.
A cardiovascular support formula built around the dietary nitrate pathway, with four clinically dosed primary actives and a complementary antioxidant blend — developed alongside a UK cardiologist.
All cited studies are available via PubMed (pubmed.ncbi.nlm.nih.gov). Daily Beets has not been independently clinically trialled as a finished product. The evidence presented here relates to individual ingredients at the dosages studied. Always consult your GP before starting any new supplement, particularly if you are taking medication.
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